Diabetic nephropathy case study
The study protocol was approved by the Ethical Committee of Faculty of Medicine, Zagazig University and informed written consent was obtained from each individual. Diabetic Nephropathy Diabetic nephropathy is one of the major complications of diabetes mellitus. Current statistics suggests that diabetic nephropathy is the leading cause of chronic kidney disease in the United States as well as many other Western societies. It is also reported to be one of the most significant long-term complications in terms of morbidity and mortality for individual patients with diabetes. Background: Diabetic nephropathy is the major micro-vascular complication of type 2 diabetes mellitus T2DM and is the main cause for end-stage kidney disease.
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Diabetic Nephropathy – Pathophysiology: An Overview
NIDDK: Family Investigation of Nephropathy and Diabetes (FIND)
Presentation R. Other medical problems include obesity and hypothyroidism. He has a history of heavy alcohol use but quit drinking alcohol 2 years ago. He is asymptomatic. There is no retinopathy or thyromegaly. There is no clinical evidence of congestive heart failure or peripheral vascular disease. Questions Does this patient have renal disease?
The Family Investigation of Nephropathy and Diabetes FIND was a multicenter observational study designed to identify genetic determinants of diabetic kidney disease. Study subjects were recruited from eleven centers and in many ethnic groups throughout the United States for a genome-wide association study GWAS. Two additional strategies were also used to localize susceptibility genes: a family-based linkage study and a case-control study using mapping by admixture linkage disequilibrium MALD. In the family-based study, participants with diabetic nephropathy were recruited with their parents and selected siblings.
Forgotten your password? Diabetic nephropathy DN is a lethal microvascular complication associated with Type 1 and Type 2 diabetes mellitus, and is the leading single cause of end-stage renal disease. Although genetic influences are important, epigenetic mechanisms have been implicated in several aspects of the disease. The current therapeutic methods to treat DN are limited to slowing disease progression without repair and regeneration of the damaged nephrons.
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